The Familial Occurrence of the Syndrome of Mid-Late Systolic Click and Late Systolic Murmur

The familial occurrence of the syndrome of mid-late systolic click and late systolic murmur.

Patients with late systolic murmurs, with and without mid-late systolic extra sounds, have recently been shown to have mitral regurgitation. This syndrome has been found to be familial in each of the four families we have studied. These families were found to have a high prevalence of mid-late systolic extra sounds, late systolic murmurs, pansystolic murmurs, abnormal electrocardiograms, and un...

The determinants of onset of mitral valve prolapse in the systolic click-late systolic murmur syndrome.

The onset of mitral valve prolapse and its close correlate, the time of systolic click, vary considerably with different physiologic and pharmacologic interventions. In order to explain the mechanism responsible for these alterations, the effects of tilt and amyl nitrite inhalation on left ventricular dynamics and the time of the systolic click were studied by analyzing echocardiograms and simu...

The syndrome of apical systolic click, late systolic murmur, and abnormal T waves.

Abnormal left ventricular contraction pattern in the systolic click-late systolic murmur syndrome.

A contraction abnormality of the left ventricle has previously been described in patients with systolic click-late systolic murmur syndrome. To determine if the contraction abnormality is present in the preprolapse period, LV dimensions and the instantaneous velocity of circumferential fiber shortening (VCF) were studied in 18 patients with the mitral valve prolapse and 16 normal subjects using...

Phonocardiogram and apex cardiogram in systolic click--late systolic murmur syndrome.